王琦
博士 副教授，四川省特聘专家
王琦，韦德bv官网医学检验系副教授，硕士生导师，斯坦福大学访问学者，复旦大学博士。从事近红外一区、二区生物荧光探针及多肽药物研究。到目前为止，在Chemical Society Reviews, Analytical Chemistry, Theranostics, Chemical Communications, Journal of Materials Chemistry B等杂志上共发表论文二十余篇，申请国家专利8项，授权4项，转化1项。担受邀任Analytical Chemistry, Chemical Science, Chemical Communications等期刊审稿人。近年来主持及参与国家自然科学基金各一项，参与科技部重大研究计划973项目一项，国家级大员工创新计划两项并获国家留学基金委资助于美国斯坦福大学研修。
研究方向：
1、多肽药物方向：基于化学固相合成法合成具有新型结构及功能的抗菌、抗肿瘤多肽，利用超分子自组装实现多肽药物的性能改进。
2、生物探针方向：开发及利用近红外荧光染料(NIR I, NIRII)结合多肽分子构建可用于生物小分子，金属离子，蛋白质检测的荧光探针。
代表论文：
1. Recent progress in the development of singlet oxygen carriers for enhanced photodynamic therapy, Guo Li, Mingmin Wu, Yongxiao Xu, Qi Wang, Jinxia Liu, Xiaobo Zhou, Haiwei Ji, Qu Tang, Xijuan Gu, Shujuan Liu, Yuling Qin*, Li Wu*, Qiang Zhao*. Coordination Chemistry Reviews, 2023, 478, 214979.
2. pH-Dominated Selective Imaging of Lipid Droplets and Mitochondria via a Polarity-Reversible Ratiometric Fluorescent Probe, Qingqing Bai, Chaojie Yang, Majun Yang, Zhaoqing Pei, Xiaobo Zhou, Jinxia Liu, Haiwei Ji, Guo Li, Mingmin Wu, Yuling Qin, Qi Wang*, Li Wu*, Analytical Chemistry, 2022, 94, 6, 2901-2911. (Cover figure, Nature Index)
3. A highly sensitive electrochemical cytosensor based on triple signal amplification strategy by using both nanozyme and DNAzyme, Jinxia Liu, Xiaodi Liu, Luxia Yang, Aiting Cai, Xiaobo Zhou*, Chu Zhou, Guo Li, Qi Wang, Mingmin Wu, Li Wu, Haiwei Ji*, Yuling Qin*, Journal of Materials Chemistry B, 2022, 10, 700-706.
4. Precisely Controlled and Deeply Penetrated Micro-Nano Hybrid Multifunctional Motors with Enhanced Antibacterial Activity against Refractory Biofilm Infections, Haiwei Ji, Haolu Hu, Qu Tang, Xiaoxia Kang, Xiaodi Liu, Lingfeng Zhao, Rongrong Jing, Mingmin Wu, Guo Li, Xiaobo Zhou, Jinxia Liu, Qi Wang, Hui Cong, Li Wu, Yuling Qin. Journal of Hazardous Materials, 2022, 436, 129210
5. Bifunctional Pdots-Based Novel ECL Nanoprobe with Qualitative and Quantitative Dual Signal Amplification Characteristics for Trace Cytokine Analysis, Jinxia Liu, Xiaodi Liu, Huanhuan Chen, Luxia Yang, Aiting Cai, Haiwei Ji*, Qi Wang, Xiaobo Zhou, Guo Li, Mingmin Wu, Yuling Qin*, and Li Wu*, Analytical Chemistry, 2022, 94 (19), 7115-7122
6. Ultrabright AIEdots with tunable narrow emission for multiplexed fluorescence imaging, Xiaobo Zhou*, Lingfeng Zhao, Ke Zhang, Chaojie Yang, Shijie Li, Xiaoxia Kang, Guo Li, Qi Wang, Haiwei Ji, Mingmin Wu, Jinxia Liu, Yuling Qin* and Li Wu*, Chemical Science, 2022, 14 (1), 113-120
7. Functionalized graphene-based electrochemical array sensors for the identification of distinct conformational states of Amyloid Beta in Alzheimer's disease, Haiwei Ji, Xiaoxia Kang, Xiaoxiao Yang, HuanhuanC hen, lvyang Zhu, Tianzhi Mao, Yue He, Jinxia Liu, Qi Wang, Xiaobo Zhou, Guo Li, Mingmin Wu, Hui Cong, Li Wu*, Yuling Qin*, Biosensors and Bioelectronics, 2022, 222, 114927
8. Ultrasensitive DNA methyltransferase activity sensing and inhibitor evaluation with highly photostable upconversion nanoparticle transducer, Mingmin Wu, Mengtian Zhang, Zhiwei Fan, Xinyue Qin, Xiaoxia Zhu, Haiwei Ji, Yuling Qin, Qi Wang*, Li Wu*, Microchimica Acta, 2021, 188:169.
9. Hemoglobin Coated Oxygen Storagable Metal-organic Framework as A Promising Artificial Oxygen Carrier, Qi Wang, Jin Gong, Qingqing Bai, Yuling Qin, Xiaobo Zhou, Mingmin Wu*, Haiwei Ji*, Li Wu*, Journal of Materials Chemistry B, 2021, 9 (19), 4002-4005. (Cover figure, hot paper)
10. Innovative Strategies for Enhanced Tumor Photodynamic Therapy, Guo Li, Qi Wang, Jinxia Liu, Mingmin Wu, Haiwei Ji, Yuling Qin*, Xiaobo Zhou*, Li Wu*, Journal of Materials Chemistry B, 2021, 9, 7347-7370.
11. A supramolecular peptide polymer from hydrogen-bond and coordination-driven self-assembly, Xiaomin Zhu, Rongfeng Zou, Qi Wang*, Junchen Wu*, Polymer Chemistry, 2018, 9, 69-76.
12. Recent advances in peptide nucleic acid for cancer bionanotechnology, Junchen Wu*, Qingchun Meng, Hongmei Ren, Hongtao Wang, and Jie Wu, Qi Wang*, Acta Pharmacologica Sinica, 2017, 38, 798-805.
13. Chitosan-coated hemoglobin microcapsules for use in an electrochemical sensor and as a carrier for oxygen, Yang Liu, Qi Wang, Pei She, Jin Gong, Weiping Wu, Shouming Xu, Jianguo Li, Kang Zhao, Anping Deng, Microchimica Acta, 2016, 183 (11), 2847-2854.
14. A novel bio-nanocomposite based on hemoglobin and carboxyl graphene for enhancing the ability of carrying oxygen, Yang Liu, Jin Gong, Weiping Wu, Yuting Fang, Qi Wang, Haiying Gu, Sensors and Actuators B: Chemical, 2016, 222, 588-597.
15. Peptide self-assembly triggered by metal ions, Rongfeng Zou,# Qi Wang,# Jingxian Wu, Junchen Wu, Carsten Schmuck and He Tian, Chemical Society Reviews, 2015, 44, 5200-5219. (#Co-first author, Nature Index)
16. A peptide probe for the detection of neurokinin-1 receptor by disaggregation enhanced fluorescence and magnetic resonance signals, Jingxian Wu, Rongfeng Zou, Qi Wang, Yajing Xue, Ping Wei, Shiping Yang, Junchen Wu* & He Tian*, Scientific Reports, 2014, 4, 6487.
17. A fluorescent light-up probe as an inhibitor of intracellular beta-tryptase, Qi Wang,# Xiuyin Shi,# Xiaoxia Zhu, Martin Ehlers, Junchen Wu*, Carsten Schmuck*, Chemical Communications, 2014, 50, 6120-6122. (#Co-first author, Nature Index)
18. Molecular Beacons of Xeno-Nucleic Acid for Detecting Nucleic Acid, Qi Wang, Lei Chen, Yitao Long, He Tian, Junchen Wu*, Theranostics, 2013, 3 (6), 395-408 (Cover figure).
19. Development and analytical validation of an Enzyme-Linked Immunosorbent Assay (ELISA) for the detection of copper in human hair and serum samples, Xiaoxia Zhu*, Qi Wang, Xiuyin Shi, Fengquan Liu, Liming Wang, Huiming Wang, Analytical Methods, 2013, 5 (10), 2578-2583.
20. A highly selective fluorescence sensor for Tin (Sn4+) and its application in imaging live cells, Qi Wang, Chunyan Li, Ying Zou, Haoxuan Wang, Tao Yi*, Chunhui Huang, Organic & Biomolecular Chemistry, 2012, 10 (33), 6740-6746.
21. Sonication-Triggered Instantaneous Gel-to-Gel Transformation, Xudong Yu, Qian Liu, Junchen Wu, Mingming Zhang, Xinhua Cao, Song Zhang, Qi Wang, Liming Chen, Tao Yi*, Chemistry-a European Journal, 2010, 16 (30), 9099-9106.
22. From vesicles to solid spheres: terminal functional group induced morphology modification, Qi Wang, Junchen Wu, Zuguang Gong, Ying Zou, Tao Yi*, Chunhui Huang, Soft Matter, 2010, 6 (12), 2679-2684.
专利：
1. 王琦;朱晓霞;刘杨;弓瑾;吴伟平;鞠少卿;顾海鹰, 一种基于纳米粒子‑血红蛋白的人造血红细胞的制备方法, 中国，申请号：201710172238.6
2. 王琦;弓瑾;吴铭敏;朱晓霞;顾心亮;张颖，一种近红外二区方酸喹啉染料及其制备方法，中国，申请号：201910242205.3.
3. 王琦;吴铭敏;马振祥;范志伟;褚修余;龚莹，一种吲哚类过氧化氢荧光探针及其制备方法,中国，申请号：CN202010617384.7
4. 王琦;马振祥;吴铭敏;褚修余;赵其杰，一种喹啉类过氧化氢荧光探针及其制备方法,中国，申请号：CN202010617354.6
5. 王琦;马振祥;吴铭敏;龚莹;赵其杰，一种苯并吲哚类过氧化氢荧光探针及其制备方法，中国，申请号：CN202010796216.9
6. 王琦;白庆庆;杨超杰;杨马骏;吴丽;冀海伟;周晓波;李国;吴铭敏，一种pH敏感的比率型半花菁-罗丹明染料及其制备方法，中国，申请号: CN202111011513.9